Learn thorough a mind map about blood coagulation and visualize the complex process of hemostasis, platelet activation, and clot formation
Here is a detailed comprehensive mind map on the topic of "Coagulation of Blood":
Central Idea: Coagulation of Blood
Main Branches:
- Initiation of Coagulation
- Coagulation Cascade
- Coagulation Factors
- Regulation of Coagulation
- Fibrinolysis
- Clinical Relevance of Coagulation
Sub-branches:
Initiation of Coagulation
- Injury to Blood Vessel
- Damage to endothelium
- Exposure of subendothelial collagen
- Release of Tissue Factor
- Expression of tissue factor on injured endothelium
- Binding of factor VII to tissue factor
- Activation of Platelets
- Release of platelet-activating factors
- Aggregation of platelets
Coagulation Cascade
- Extrinsic Pathway
- Activation of factor VII by tissue factor
- Activation of factor IX and X
- Intrinsic Pathway
- Activation of factor XII by contact with collagen
- Activation of factor XI and IX
- Common Pathway
- Activation of factor X by factor IXa
- Activation of prothrombin (factor II) by factor Xa
- Conversion of fibrinogen to fibrin by thrombin
Coagulation Factors
- Vitamin K-Dependent Factors
- Factor II (prothrombin)
- Factor VII (proconvertin)
- Factor IX (Christmas factor)
- Factor X (Stuart factor)
- Contact Factors
- Factor XII (Hageman factor)
- Factor XI (plasma thromboplastin component)
- Prekallikrein
- High-molecular-weight kininogen
- Fibrinogen and Fibrin
- Factor I (fibrinogen)
- Fibrin
Regulation of Coagulation
- Anticoagulant Pathways
- Protein C pathway
- Antithrombin III
- Tissue factor pathway inhibitor (TFPI)
- Fibrinolysis
- Plasminogen activators (t-PA, u-PA)
- Plasminogen
- Plasmin
- Coagulation Inhibitors
- Antithrombin III
- Protein C
- Protein S
- Thrombomodulin
Fibrinolysis
- Plasminogen Activation
- Activation of plasminogen by t-PA or u-PA
- Fibrin Degradation
- Degradation of fibrin by plasmin
- Formation of fibrin degradation products (FDPs)
Clinical Relevance of Coagulation
- Bleeding Disorders
- Hemophilia A (factor VIII deficiency)
- Hemophilia B (factor IX deficiency)
- Von Willebrand disease
- Thrombotic Disorders
- Deep vein thrombosis
- Pulmonary embolism
- Arterial thrombosis
- Coagulation Disorders in Pregnancy
- Preeclampsia
- HELLP syndrome
- Coagulation Disorders in Cancer
- Disseminated intravascular coagulation (DIC)
This mind map provides a comprehensive overview of the coagulation process, including the initiation of coagulation, the coagulation cascade, coagulation factors, regulation of coagulation, fibrinolysis, and clinical relevance of coagulation.
